In an interview with a sound effects guy, he was asked if there was one they couldn't use or something to that effect. "Oh, yes" they had needed a sound effect for a body hitting pavement and had the bright idea to get up on a ladder with a watermelon... only the resulting sound was too gruesomely suggestive to be used in the movie. I can personally attest that a large piece of pumpkin from about 180 feet onto a stone terrace is pretty good.
I heard of an experiment about excluding surrounding sounds one could perceive.
The person was in a maximally sound proof room, and the frightening sound of the heart thumps is what one then hears most.
Another horrible one is the sound of a shameless politician when they change the tone and inflection of their voice in a patronzing and sad attempt to appeal to a group with which they have no real connection. Prime example: