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moosedrool

Trad climber
lost, far away from Poland
Jan 7, 2013 - 02:11pm PT
Tony B, questioning my sincerity?

OK. A little bit of a background info. In my own words:
Proteins in human bodies are made according to the instructions encoded in our genes (stretches of DNA). So called genetic defects are the damages to the cell's DNA that render the cell unable to make a key protein. If one could restore the DNA in that cell, the cell would be cured. The trick is to find a "vehicle" that would deliver the DNA into a specific cell.

When I was a scientist at Bayer in Richmond, CA, I joined the Gene Therapy group. Our project was to create a vehicle that would deliver a gene (DNA) into specific human cells. At the same time, the vehicle had to protect the DNA from enzymatic degradation (if you just inject DNA to your body, it would be degraded by the enzymes). To create the vehicle, we used a protein (called VP1) from the polyoma JC virus. This protein can create a ball-like structure (about 50 nm diameter) when 360 of them join together. Inside the ball there is enough space to put a piece of DNA encoding a small protein. My tasks in our group were to: find a way to purify the VP1 protein and assemble them around a piece of DNA. In addition, I created analytical methods that monitored that process and then showed that the vehicle was properly assembled. The project was successful. Using the vehicle, we delivered the green fluorescent protein to a target human cells (on a dish). After the cells expressed the gene, the cells turned green. Also, the gene was protected from the enzymes.
Shortly after that, the project was shelved. At least I could write an article about it :). My work draw enough interest to be cited in the Encyclopedia of Life Sciences.

Man, I love to brag!
Tony Bird

climber
Northridge, CA
Jan 7, 2013 - 02:17pm PT
sincerity? not at all, you are refreshingly sincere. my problem is with your statement, "I am reading your material, It is fair you read some of mine." that's a complete non-sequitur. if you're trying to impress me as an intelligent scientist working in the chemistry of dna, you don't have to do that. we're not talking about your research area here.
moosedrool

Trad climber
lost, far away from Poland
Jan 7, 2013 - 02:43pm PT
Tony B, be a good sport. First you asked me to make it more clear for you:

you must first interest me in your material, moosedrool, which you have thus far--how can i say this gently--failed to do.

and then you scolded me for doing so?

we're not talking about your research area here.

High Fructose Corn Spirit

Gym climber
-A race of corn eaters
Jan 7, 2013 - 03:18pm PT
I'm adding this here only because I wanted to further reinforce the idea in my own working vocabulary...

i came to respect klimmer for standing his ground, probably taking more heat than anyone has ever gotten on supertopo.

Standing your ground in bullshi't is nothing to be proud of.
selfish man

Gym climber
Austin, TX
Jan 7, 2013 - 04:04pm PT
you and healyje get on my case like flies on sh#t, dirtbag. remember, when it comes to flies and sh#t, that the attraction does not reflect well on the flies.

I didn't read the discussion but couldn't help laughing when I saw this. Neither does it reflect well on what attracts the flies, I'm afraid

moosedrool

Trad climber
lost, far away from Poland
Jan 7, 2013 - 05:46pm PT
Tony B, sorry but all those claims about extraterrestrials have not been confirmed by any respectable scientific journal. As a scientist I have to scrutinize the evidence before I make my conclusions. The evidence about extraterrestrials, illuminati, chemtrails, 9/11 cover-up, and such all fall into the category of BELIEFS. The same as religion, it asks you to believe without and in spite of evidence. It is fascinating for me to see how some atheists converted to conspiracists. Why do they want to believe in such nonsense? Because it is all in their genes!

mechrist

Gym climber
South of Heaven
Jan 7, 2013 - 05:59pm PT
OMG, it is so hard to believe... but someone said it on the internet, so you never know...

http://gawker.com/5969532/the-insane-sandy-hook-conspiracy-theories-that-are-already-flooding-facebook-and-twitter


Blonde girls...


Parents... or attourney...


Illuminati...

monolith

climber
albany,ca
Jan 7, 2013 - 06:11pm PT
^^Werner's been busy getting the Truth out.^^

Wake up Sheeple!
moosedrool

Trad climber
lost, far away from Poland
Jan 7, 2013 - 06:16pm PT
Mechrist. I am not sure whether I should laugh or cry. America the Ignorant, so true...
mechrist

Gym climber
South of Heaven
Jan 7, 2013 - 06:21pm PT
But it is interesting how they all line up in a pentagram... with Columbine and Aurora in southern WY... which is the state where Cheney lives...

Eh, you never know...
Tony Bird

climber
Northridge, CA
Jan 7, 2013 - 06:39pm PT
those whose careers are tied to "respectable scientific journals" will never think for themselves, drool. you have obviously never examined the evidence of ufology personally, else you would be addressing its worth or worthlessness in terms of the evidence itself, rather than "respectability". my advice is stick with your career, your great humility, and your comfy lab. it's dangerous out there. you'll find plenty of fellowship from the school of baby sharks we're attracting--they had a term for it a few years ago: dittoheads.

one of our respectable scientists on this forum recently reported going to a conference where most of the papers were not recognizable, to him, as science. what i recognized in terms of the general subject matter was an interest in areas rumored to involve back-engineering. yes, technology supposedly gained from alien contacts kept secret from the public. in certain circles, it would appear that respectability is being thrown to the wind.
healyje

Trad climber
Portland, Oregon
Jan 7, 2013 - 06:40pm PT
michael salla

Salla? Please, how can you buy that drivel? It's classic scifi hucksterism.

pardon me if i'm not impressed by technical language

Or facts. Why exactly is it that topics which sport a total lack of support by any documented facts seem to impress you far more than any others? Which brings us to:

you have obviously never examined the evidence of ufology personally, else you would be addressing its worth or worthlessness in terms of the evidence itself, rather than "respectability"

But then, of course, there is zip, zero, nada "evidence" of UFOs - as in none whatsoever.

yes, technology supposedly gained from alien contacts kept secret from the public.

It's always the same troop of crank inventors along with scifi jugglers, clowns, and folks hoping to turn a buck in retirement (and the suckers they attract).

mechrist

Gym climber
South of Heaven
Jan 7, 2013 - 06:42pm PT
I watched ET when I was young and I think it could happen.
WBraun

climber
Jan 7, 2013 - 06:42pm PT
I had nothing to do with mechrist's troll.

So fuk you Monolith ......
Ghost

climber
A long way from where I started
Jan 7, 2013 - 06:44pm PT
Just when you thought it couldn't get any sillier...

those whose careers are tied to "respectable scientific journals" will never think for themselves,

Tony Bird

climber
Northridge, CA
Jan 7, 2013 - 06:54pm PT
i think salla is a little gullible, healyje, but he's someone who will delve into areas no one else will touch, and he comes up with very interesting information--sometimes. but the medvedev stuff has little to do with salla. salla just reported what got buzzed about all over the world when the PM made his supposed off-camera remarks.

i tend to agree with moosedrool's assessment: medvedev is a fox and knew perfectly well what he was doing and was testing the waters for a reaction. the link to the russian men in black is interesting too. it's just a basic documentary on ufology, portraying experiences which are almost identical to those which happen in the u.s. the difference between us and russia is our movie industry. the movies portray all the latest from ufology, fictionalizing it and keeping it in our tabloid mindset, where we won't take it too seriously. hollywood sci fi has no imagination as far as this stuff goes. it picks up stories and themes which a lot of people consider real, and which some claim really to have experienced.

salla made a couple reports last year about the real reasons for our current, outrageous trade imbalance with communist china. it has nothing to do with ufos, ET or sci fi. it begins with a lot of stolen money during world war 2. it's the closest thing to real investigative reporting on that very important issue that i've seen anywhere.
healyje

Trad climber
Portland, Oregon
Jan 7, 2013 - 07:31pm PT
salla made a couple reports last year about the real reasons for our current, outrageous trade imbalance with communist china. it has nothing to do with ufos, ET or sci fi. it begins with a lot of stolen money during world war 2. it's the closest thing to real investigative reporting on that very important issue that i've seen anywhere.

And of course you buy it hook, line and sinker with no critical thought whatsoever because, of course, the fed and their minion central banks are all an evil conspiracy. Sigh.
Don Paul

Big Wall climber
Colombia, South America
Jan 7, 2013 - 09:00pm PT
moosedrool, my opinion on religion and evolution has always been that the idea of immortality of the soul, a divine protector, eternal paradise are so motivating that they give people a survival benefit compared to people who think their lives are insignificant and that death is the end. It doesnt matter if its true or not, believing it is beneficial. Sort of like believing that rp's and lowe-balls can protect you in a fall.

A second explanation could be that feelings of wonder and mystery about the world, which tend to ascribe everything to God, is a kind of scientific curiosity, and even if the conclusions arent right, its better than not thinking about the world at all. The most primitive spiritual thoughts, 50,000 years ago, led to progress, and we havent evolved much since then.

What did yo think about the Japanese researchers who claim to be able to program cells to go after cancer cells? It would be so amazing to see a cure for cancer in my lifetime.
High Fructose Corn Spirit

Gym climber
-A race of corn eaters
Jan 7, 2013 - 09:44pm PT
dp, that's an insightful post, really.

Applicable to primitive man, but arguably less so for modern man. What's modern man esp with his science edu to do. Should he live with one foot in reality, the other in escapist fantasy - employing either (depending how one looks at it) cognitive dissonance or non-overlapping magisteria.

Perhaps one foot in and one foot out (toggling back n forth) is the best life strategy for going forward for the most nimble minds of the future. (??)

Moreover, insofar as "elements" of religion or theology are part of our makeup (having evolved together in symbiosis over thousands of generations) - in other words, insofar as they are part of our blood or our dna - does not this toggling strategy make the most sense? Would it not be the most "reasonable" to employ?

Just food for thought.

And then there's this: With all these new pressures set against modern man (due to his rapidly changing environment including rapidly changing awareness of his place in the cosmos) causing angst, depression, ennui - should he utilize pharmaceuticals (as umpteen millions have already begun to do esp in their later years) to deal with these pressures which would arguably screw with the scythe of natural selection (not unlike eyeglasses or hernia repair), and which would addict him (wed him) to this technology.

One argument could be: Why not just lean toward the traditional fantasy (thousands of generations in the making) to get yourself through your day and your life rather than the pills? What's the diff really?

On your last point, though such a cure (under the battle hymn: "Kill Cancer!") would be a great scientific achievement it would ultimately spell ecological disaster at unprecedented scales.
donini

Trad climber
Ouray, Colorado
Topic Author's Reply - Jan 7, 2013 - 09:46pm PT
On a climbing trip.....glad everyone is having so much fun!
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