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matisse
climber
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Topic Author's Original Post - Sep 3, 2013 - 01:24pm PT
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Dearest Supertacoans.
Finally I get to do something other than write grants and shuffle papers around my desk. I have a new research study just starting in the fall and I need subjects aged 19-45 who have had HAPE diagnosed by a physician. At this point I am just recruiting the HAPE-suceptible (the people who have been to altitude without getting sick are easy to find).
I will post the official flyer (approved by our IRB) below.
If you are interested and think you fit the bill as a subjects you can contact Mike Patz (contact below) or shoot me a PM. If you are just generally interested in our research shoot me a PM and I can forward you a reprint of a similar study.
Sue
official recruitment notice:
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Volunteers needed for high altitude pulmonary edema (HAPE) research study
We are seeking volunteers for a research study aimed to improve our understanding of high altitude pulmonary edema (HAPE). HAPE is a condition where the lungs fill with fluid upon ascent to high altitude. The study will involve magnetic resonance imaging (MRI) of the lungs and will also involve short periods of breathing low levels of oxygen similar to being at high altitude. We are looking for volunteer research participants between 18 and 45 years old who have had HAPE, previously diagnosed by a Doctor. We are also seeking volunteers who have been to high altitude, but have never experienced any altitude related illness.
What volunteers will do in the study: There will be two parts to the study. The first part lasts approximately 45 minutes and will involve a medical examination to ensure you qualify for the study and some tests of your lung function. In the second part, which will last about 4 hours divided into two 2 hour sessions, you will breathe air from a mask while MRI images of your lungs are obtained. You will also be asked to briefly inhale and exhale different gas mixtures including 100% Oxygen and 12.5% Oxygen (equivalent to being at 12,500 ft).
The study will take place in San Diego, Ca and will be run by researchers from the University of San Diego Medical Center and the University of Washington Medical Center.
For more information, please contact
Michael Patz MD
Resident Physician and Bonica Research Scholar
Department of Anesthesiology, Critical Care, and Pain Medicine.
Email – mpatz@uw.edu
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Ed Hartouni
Trad climber
Livermore, CA
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bump this up... hopefully there are some who fit the criteria...
and I'm always interested, send you a pm when I get home tonight!
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Reilly
Mountain climber
The Other Monrovia- CA
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Uh, Ed, I'm not positive but did you read the fine print?
"subjects aged 19-45"
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Ed Hartouni
Trad climber
Livermore, CA
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totally read it, so not only being 59.666666666666666666666666666666666666666666666667 (and counting) I've never been diagnosed with HAPE, by myself or a physician...
but I'd love to read the report, thus the pm...
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Michelle
Social climber
1187 Hunterwasser
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I'm with Ed, I totally want to see the report too. I meet the age but not the other criteria, unless being stupidly dehydrated at altitude then hopping into a hot spring, causing mega headache and vomiting counts..
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matisse
climber
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Topic Author's Reply - Sep 3, 2013 - 04:30pm PT
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We published this a while back and will be building on the work described here. Unfortunately the American Thoracic Society which publishes this journal has not been very good about open access for older work, and this was published before Biomed central (which offers public access for content > one year old) was up, and besides I wasn't NIH funded for this work.
Some of you may be able to download the pdf, if you can't just shoot me a mail.
here is the link
http://www.atsjournals.org/doi/abs/10.1164/rccm.200406-707OC
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ron gomez
Trad climber
fallbrook,ca
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Hey Matisse, sounds like it could be a good study. Couple of questions:
1). How high of an altitude is the study looking for in the group that has been to atitude with no symptoms? Is there an age restriction on this study group?
2). Are you guys attempting to find out if the lung is more likely to have an uneven distribution of blood following HAPE(lung damage), thus less O2 saturation at less pressure due to the uneven distribution?
Good luck with the study, let us know when it gets going or when info comes out on it.
Peace
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Ed Hartouni
Trad climber
Livermore, CA
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thanks matisse got the .pdf off of your link...
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matisse
climber
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Topic Author's Reply - Sep 3, 2013 - 05:34pm PT
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Hi Ron,
The age range is the same. 45 and under. The IRB isn't too thrilled if we make people much over 45 hypoxia even if they do it to themselves all the time. Sometimes it is easier just not to fight city hall. As for altitude the higher the better. Prefer above 16-18 k (i.e outside of sierra, lower 48).
We don't think that the uneven blood flow is a function of having had HAPE but one of the reasons that predisposes to HAPE. Part of the reason we think that is that we think that what incites HAPE is uneven pressure causing capillary rupture, that then triggers HAPE, but we are pretty sure that some athletes get capillary rupture at maximal exercise at sea level and there is no evidence that they have a predisposition to HAPE. We are exploring some other aspects of the uneven blood flow.
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ron gomez
Trad climber
fallbrook,ca
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Thanks for the response, I live in the area and was interested, but I, like Hartouni am an old geezer(not calling Ed a geezer though!)so I'm eliminated from volunteering. Interesting subject...I always guessed that one mechanism could be decreased partial pressure in the lungs at altitude could cause an inflamation of the aveoli, thus allowing fluid that is already there, or a result of the inflamation to fill the sacks. Once the aveoli have been filled with fluid it renders them "stretched" out for lack of better words and then predisposing them to future insults.
Question: Do you know if incidences of pnuemonia also predisposes one to HAPE? Same basic mechanism of fluid in the lung.
Peace
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matisse
climber
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Topic Author's Reply - Sep 3, 2013 - 06:35pm PT
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People have thought that inflammation was the primary problem, but now have changed their minds for the most part. No evidence that prior pneumonia predisposes to HAPE, although if you have an upper respiratory infection at the time you go to altitude you are more vulnerable (we don't know why). Pretty good evidence that the initial insult is mechanical (i.e. pressure related breaks) and then you get the inflammation. The study that changed everyone's mind is this one:
http://jama.jamanetwork.com/article.aspx?articleid=194880
I am pretty sure JAMA is open content for this far back.
Basically they took HAPE susceptible and HAPE resistants to 4559m and did bronchoscopy and bronchoalveolar lavage (i.e. stuck a fiberoptic tube in the airway and washed out some of the fluid in the lung). Some but not all of the HAPE susceptible got HAPE (They have a crew of regular subjects who volunteer a lot). There were differences between the resistants, the HAPE who were well and the HAPE who were sick. The biggest difference though was the amount of red blood cells in the sick HAPE subjects was much higher than the other 2 groups indicating breaks and since it was very early in the disease there weren't elevated concentrations of inflammatory mediators, indicating the breaks came first.
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matisse
climber
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Topic Author's Reply - Sep 3, 2013 - 07:46pm PT
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^^^^^^^^^^^ ?
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donini
Trad climber
Ouray, Colorado
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Take me, take me.....three for the price of one given your age parameters.
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matisse
climber
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Topic Author's Reply - Sep 3, 2013 - 09:26pm PT
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Ahh. Ding I am old. I don't remember stuff anymore. This one is at sea level, but I will bake cookies on request for subjects :)
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matisse
climber
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Topic Author's Reply - Sep 9, 2013 - 02:46pm PT
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Monday morning BUMP to help (awesome badass climber) Mike recruit subjects
for our study. ^^^^^^^^^^^^^^^^^^^ for climbing content.
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matisse
climber
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Topic Author's Reply - Sep 11, 2013 - 04:08pm PT
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I'm now starting to recruit the "Control" subjects. If you are 45 years or younger, are located somewhere near So Cal, and have been repeatedly to high altitude and preferably above 18k feet, and have never had HAPE and little to no AMS, are otherwise healthy (except for some strange obsession with mountains and/or rocks) shoot me a PM or contact Mike Patz at the email listed in post #1.
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Toker Villain
Big Wall climber
Toquerville, Utah
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Sep 11, 2013 - 06:38pm PT
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I bet you could get the Sherpas fighting over who gets this job.
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ontheedgeandscaredtodeath
Social climber
SLO, Ca
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Sep 11, 2013 - 06:56pm PT
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Hi Matisse,
How many times is repeatedly? Not being a smart ass, just seeing if I can help.
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matisse
climber
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Topic Author's Reply - Sep 11, 2013 - 07:04pm PT
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^^^^^
I dunno depends on how high. shoot me a mail if you are interested and even remotely think you fit the bill. I have several people who waltz around the sierra a bunch (like most of us) but right now not that many who have been higher that 14k at all. so a bunch of sierra time, plus a mexican volcano or 2 would be beautimous.
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ontheedgeandscaredtodeath
Social climber
SLO, Ca
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Sep 11, 2013 - 07:16pm PT
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Alright-- I sent you an e-mail through your taco account.
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